ALS Highlights the Mechanism of DNA Synthesis Publication

The Advanced Light Source at the Berkeley Lab highlights the Chaput lab’s recent publication on the mechanism of DNA synthesis in a Science Brief. The specific Nature Communication publication discusses newly discovered intermediates that provide greater context to replication by a DNA polymerase; the exact order and transition between intermediates was solved by time-resolved X-ray crystallography. This structural understanding was obtained with hundreds of protein samples that were prepared and harvested, and then analyzed at the Advanced Light Source Beamlines.